Academic Title: Professor
Campus: St. George
CSB Appointment: Full
Primary Undergraduate Department:
Cell & Systems Biology
Cell & Systems Biology
Ph.D. University of Cologne 1990
Lab Manager and Research Associate
I received my training in Molecular Biology and Genetics at the University of Toronto.
Over the years I have worked on a broad range of projects, such as generation of mutants and research tools to study the role of Alpha-catenin in establishing and maintaining epithelial polarity.
Most notably I was involved in the investigation of the role of Crumbs in Drosophila photoreceptor cell integrity. My recent work includes further analysis of Crb mutant isoforms that affect rhodopsin trafficking, resulting in Crb-dependent retinal degeneration.
Currently I am investigating the function of Yurt during early embryonic development, and generating new tools for lineage analysis and live imaging.
My interests also include the latest in technological and research advances and incorporating/ implementing these in our research work.
In my free time I sail and enjoy nature walks.
CURRENTLY IN THE LAB...
Hailing from Barbados, West Indies, Luka received the
Barbados Scholarship in 2009 which allowed her to pursue undergraduate studies in Cellular and Molecular Biology and Visual Studies at the University of Toronto. She first joined the Tepass lab during a fourth year research project and decided to continue into a PhD here. She is part of the alpha-catenin research group, focussing on live imaging analysis in the early embryo. In her free time, she dances ballet and contemporary.
Senior Research Associate
Ritu obtained her PhD degree from TIFR, Mumbai, where she worked with Professor Krishanu Ray and collaborated with Daniel Eberl (University of Iowa) on understanding intracellular transport in Drosophila. Specifically, she investigated the role of Drosophila Kinesin Accessory Protein, a sub-unit of the Kinesin-II motor protein complex, in anterograde intraflagellar transport.
She joined the Tepass lab in 2005 as a Postdoctoral Fellow and was later appointed a Senior Research Associate. Her research contributions include developing Drosophila as a model system to elucidate the molecular function of alpha-catenin in vivo, and to understand how it organizes the cadherin-actin interface. Her work has implications for understanding how loss of the cadherin-catenin complex, and consequently the adherens junctions, promotes cancer progression and metastasis.
She likes to go for hikes, participate in bikeathons, and play badminton and tennis.
Kenana al Kakouni
I work on polarized trafficking in epithelial cells. Particularly, I'm interested in studying the role of trafficking in embryonic epithelia using live imaging.
When I am not in the lab, I enjoy reading, photography and playing board games. I've lived most of my life in Toronto and one of my favorite things about this city is the number of sushi restaurants. I love sushi!
David ter Stal
In the lab, my work is on the regulation of epithelial polarity through post-translational modifications of the apical polarity regulator Crumbs, with a focus on its interactions with the FERM domain containing protein Yurt, and the kinase aPKC. My personal interests include photography, auto racing, and playing board games.
Sérgio Simões, Ph.D.
Post-Doctoral Research Fellow
During my PhD in Dr. Antonio Jacinto’s lab, Portugal, I studied how signaling mediated by Rho1 GTPase is temporally and spatially controlled during morphogenesis via RhoGEFs and RhoGAPs, using epithelial cell invagination in the Drosophila embryo as a model system. In Dr. Jennifer Zallen’s lab, at MSKCC, New York I addressed molecular mechanisms implicated in the establishment and maintenance of planar polarization of epithelial cells during convergence and extension movements in the Drosophila gastrula. In Ulrich Tepass’s lab, Toronto, Canada, I have been investigating how Drosophila neural stem cells or neuroblasts loose cell-cell contacts and apical-basal polarity in order to squeeze out of the epithelium, a process termed neuroblast ingression. Ingression of epithelial cells is ubiquitous during development and plays key roles in carcinoma progression and metastasis.
Azadeh is currently a PhD student at the Tepass lab. Her project is about polarized vesicle trafficking in the Drosophila photoreceptor cells (PRCs). She is specifically interested in understanding how proteins are targeted to the apical membrane of the PRCs. Her research has implications in understanding various retinal degenerative diseases, such as Retinitis Pigmentosa.
Azadeh enjoys teaching and is also interested in finding ways to communicate scientific ideas with the general public.
As a PhD student in the Tepass lab, I examine the role of epithelial cell polarity during symmetric cell division. More importantly, I am trying to elucidate the exact mechanisms by which the polarity machinery influence the process of cell division. Both cell division and epithelial polarity have been attributed to tumour progression, and thus better understanding of the relationship between the two is of great interest to me.
I have a number of hobbies outside the lab such as rock climbing, gardening, stargazing, photography and recently I've been trying my hands at selectively breeding ornamental shrimps!
I am a MSc student focusing on the early stages of Drosophila oogenesis. Specifically, I am analyzing follicle stem cell (FSC) proliferation and subsequent follicle cell intercalation in regards to the FERM domain protein, Okapi. Okapi mutants give rise to a wide range of defects, all believed to arise early on in oogenesis within the latter regions of the germarium, where FSCs reside and FSC progeny intercalation and differentiation occurs.
I love my family and my lazy dog above all else, and I have them to thank for all of my achievements. I am a die-hard Toronto Raptors fan, and also an avid fan of the Halo Universe with which I have been captivated with since day one.
Lidia is one of the newer additions to the Tepass lab, having started her MSc. degree in 2016. Prior to joining the Tepass lab, she attended York University, where she gained experience primarily in tissue culture research. Her current project focuses on alpha-catenin - an adherens junctions protein that, in addition to adhesion, is involved in various growth regulation pathways. She is specifically interested in alpha-catenin's role in the Drosophila wing disc - a commonly used model for studying growth. In her free time, Lidia enjoys writing and is an avid reader with a particular interest in classics and crime fiction.
A long-term Torontonian, I have spent most of my academic years in this beautiful, bustling city. I completed an Honours Bachelor of Science at the University of Toronto, with a specialization in Cell and Molecular Biology, in addition to a major in Health & Disease. Through my research projects during my undergraduate years, I gained experience working with both in vitro and in vivo systems, and learning biochemistry, molecular biology, and immunohistochemistry techniques. I joined the Tepass lab as a new graduate student in September 2016, where I currently study the role of polarity protein Crumbs (Crb) – a conserved type I transmembrane protein- as a growth regulator during development in Drosophila. To investigate its function, I focus on the role of Crb in imaginal wing discs, a model tissue for studying growth. In my spare time I enjoy the thrilling sport of reading classics, gardening and crocheting!