Neuroblast ingression
Neuroblast ingression

Ventral view of a Drosophila embryo showing neuroblasts highlighted by the expression of the transcription factors Snail (Snail::GFP, green) and Achaete (anti-Achaete antibody, red). The embryo is also stained for the adhesion molecule Drosophila E-cadherin (anti-DEcad antibody, blue) to mark cell outlines in the ectodermal epithelium from which neuroblasts ingress. Anterior is at the top. Image © 2017 Simões et al.

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Structure function analysis
Structure function analysis

α-catenin mutant cells lose adhesion and detach from each other in the follicular epithelium of the Drosophila egg chamber.

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Lumen Formation
Lumen Formation

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Neuroblast ingression
Neuroblast ingression

Ventral view of a Drosophila embryo showing neuroblasts highlighted by the expression of the transcription factors Snail (Snail::GFP, green) and Achaete (anti-Achaete antibody, red). The embryo is also stained for the adhesion molecule Drosophila E-cadherin (anti-DEcad antibody, blue) to mark cell outlines in the ectodermal epithelium from which neuroblasts ingress. Anterior is at the top. Image © 2017 Simões et al.

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PUBLICATIONS

2019

Laffafian, A., & Tepass, U. (2019). Identification of genes required for apical protein trafficking in Drosophila photoreceptor cells. G3: Genes, Genomes, Genetics, 9(12), 4007-4017.

Sarpal, R., Yan, V., Kazakova, L., Sheppard, L., Yu, J. C., Fernandez-Gonzalez, R., & Tepass, U. (2019). Role of α-Catenin and its mechanosensing properties in regulating Hippo/YAP-dependent tissue growth. PLoS genetics, 15(11), e1008454.

Silver, J. T., Wirtz-Peitz, F., Simões, S., Pellikka, M., Yan, D., Binari, R., ... & Tepass, U. (2019). Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly. The Journal of cell biology, jcb-201807106.

2018

Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., ... & Yonemura, S. (2018). Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions. Nature communications, 9(1), 5121.

2017

Pellikka, M., & Tepass, U. (2017). Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein crumbs. J Cell Sci, jcs-197178.

Simões, S., Oh, Y., Wang, M. F., Fernandez-Gonzalez, R., & Tepass, U. (2017). Myosin II promotes the anisotropic loss of the apical domain during Drosophila neuroblast ingression. J Cell Biol, 216(5), 1387-1404.

2016

Simoes, S., & Tepass, U. (2016). Muscle versus Snail: Muscle wins. The Journal of cell biology, 212(2), 139-141.

2015

Houssin, E., Tepass, U., & Laprise, P. (2015). Girdin-mediated interactions between cadherin and the actin cytoskeleton are required for epithelial morphogenesis in Drosophila. Development, 142(10), 1777-1784.

Escobar, D. J., Desai, R., Ishiyama, N., Folmsbee, S. S., Novak, M. N., Flozak, A. S., ... & Leckband, D. (2015). α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism. J Cell Sci, 128(6), 1150-1165.

2014

Tepass, U. (2014). Developmental biology: Polarize to elongate. Nature, 515(7528), 499-501.

2013

Desai, R., Sarpal, R., Ishiyama, N., Pellikka, M., Ikura, M., & Tepass, U. (2013). Monomeric α-catenin links cadherin to the actin cytoskeleton. Nature cell biology, 15(3), 261-273.

2012

Tepass, U. (2012). The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival. Annual review of cell and developmental biology, 28, 655-685.

Sarpal, R., Pellikka, M., Patel, R. R., Hui, F. Y. W., Godt, D., & Tepass, U. (2012). Mutational analysis supports a core role for Drosophila α-catenin in adherens junction function. J Cell Sci, 125(1), 233-245.

 

2011

Laprise, P., & Tepass, U. (2011). Novel insights into epithelial polarity proteins in Drosophila. Trends in cell biology, 21(7), 401-408.

 

2010

Harris, K. P., & Tepass, U. (2010). Cdc42 and vesicle trafficking in polarized cells. Traffic, 11(10), 1272-1279.

Harris, T. J., & Tepass, U. (2010). Adherens junctions: from molecules to morphogenesis. Nature reviews Molecular cell biology, 11(7), 502-514.

Laprise, P., Paul, S. M., Boulanger, J., Robbins, R. M., Beitel, G. J., & Tepass, U. (2010). Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway. Current Biology, 20(1), 55-61.

 

2009

Urbano, J. M., Torgler, C. N., Molnar, C., Tepass, U., López-Varea, A., Brown, N. H., ... & Martín-Bermudo, M. D. (2009). Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis. Development, 136(24), 4165-4176.

Koehler, A., Desser, S., Chang, B., MacDonald, J., Tepass, U., & Ringuette, M. (2009). Molecular evolution of SPARC: absence of the acidic module and expression in the endoderm of the starlet sea anemone, Nematostella vectensis. Development genes and evolution, 219(9-10), 509-521.

Tepass, U. (2009). FERM proteins in animal morphogenesis. Current opinion in genetics & development, 19(4), 357-367.

Karpowicz, P., Pellikka, M., Chea, E., Godt, D., Tepass, U., & van der Kooy, D. (2009). The germline stem cells of Drosophila melanogaster partition DNA non-randomly. European journal of cell biology, 88(7), 397-408.

Laprise, P., Lau, K. M., Harris, K. P., Silva-Gagliardi, N. F., Paul, S. M., Beronja, S., ... & Tepass, U. (2009). Yurt, Coracle, Neurexin IV and the Na+, K+-ATPase form a novel group of epithelial polarity proteins. Nature, 459(7250), 1141-1145.

Godt, D., & Tepass, U. (2009). Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration. Nature cell biology, 11(5), 536-538.

Swanson, L. E., Yu, M., Nelson, K. S., Laprise, P., Tepass, U., & Beitel, G. J. (2009). Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization. Genetics, 181(4), 1281-1290.

 

2008

Harris, K. P., & Tepass, U. (2008). Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis. J Cell Biol, 183(6), 1129-1143.

2007

Lee J.D., Silva-Gagliardi, N.F., Tepass, U., McGlade, C.J. and Anderson, K.V. (2007). The FERM protein Epb4.1l5 is required for organization of the neural plate and the epithelial-mesenchymal transition at the primitive streak of the mouse embryo. Development 134, 2007-2016.

 

Tepass, U. and Harris, K.P.  (2007). Adherens junctions in Drosophila retinal morphogenesis. Trends Cell Biol. 134, 26-35. 

2006

Husain, N., Pellikka, M., Hong, H., Klimentova, T., Choe, K. M., Clandinin, T. R., & Tepass, U. (2006). The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina. Developmental cell, 11(4), 483-493.

Laprise, P., Beronja, S., Silva-Gagliardi, N. F., Pellikka, M., Jensen, A. M., McGlade, C. J., & Tepass, U. (2006). The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size. Developmental cell, 11(3), 363-374.

2005

Mehta, S.Q., Hiesinger, P.R., Beronja, S., Zhai, R.G., Schulze, K.L., Verstreken, P., Cao, Y., Zhou, Y., Tepass, U., Crair, M.C., and Bellen, H.J. (2005). Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron 46, 219-32.

 

Tepass, U. and Godt, D. (2005). Talin’s second persona. Nat. Cell Biol., 7, 443-444. 

 

Beronja, S., Laprise, P., Papoulas, O., Pellikka, M., Sisson J. and Tepass U. (2005). Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells. J. Cell Biol. 169, 635-646. 

 

D'Alterio, C., Tran, D., Au Yeung, M.W.Y., Hwang, M.S.H., Li, M.A. Mulligan, V., Arana, C., Sharma, P., Kubesh, M., Chase, M., Tepass, U. and Godt, D. (2005). Drosophila Cad99C, the orthologue of human Usher cadherin PCDH15 controls microvilli morphogenesis. J. Cell Biol. 171, 549-558.

 

2004

Wu, V.M., Schulte, J., Hirschi, A., Tepass, U. and Beitel, G.J. (2004). Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. J Cell Biol. 164, 313-323. 

Smith, C.A., Dho, S.E., Donaldson, J., Tepass, U. and McGlade, C.J. (2004). The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol. Biol. Cell. 15, 3698-3708. 

Paladi M. and Tepass, U. (2004). Function of Rho GTPases in embryonic blood cell migration in Drosophila. J. Cell Sci., 117, 6313-26.

Ready, D. and Tepass, U. (2004). Crumbs-Dependent Epithelial Organization in Retinal Morphogenesis and Disease. In: Photoreceptor Cell Biology and Inherited Retinal Degenerations; edited by David S Williams, World Scientific Press, pp 1-21. 

 

2003

Tanentzapf, G. and Tepass U. (2003). Interactions between the crumbs, lethal giant larvae, and bazooka pathways in epithelial polarization. Nat. Cell Biol. 5, 46-52.

Schulte, J., Tepass, U., and Auld, V. (2003). Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila. J. Cell Biol. 161, 991-1000. 

Tepass, U. (2003) Claudin complexities at the apical junctional complex. Nat. Cell Biol. 5, 595-597.

Mehalow, A.K., Kameya, S., Smith, R.S., Hawes, N.L., Denegre, J.M., Young, J.A., Bechtold, L., Haider, N.B., Tepass, U., Heckenlively, J.R., Chang, B., Naggert, J.K. and Nishina, P.M. (2003). CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina. Hum Mol Genet. 12, 2179-2189.

Godt, D. and Tepass, U. (2003a). Organogenesis: keeping in touch with the germ cells. Curr. Biol. 13, 683-685.

Godt, D. and Tepass, U. (2003b). Hand-me-downs. Transmitting anterior-posterior asymmetry from older to younger egg follicles. Dev. Cell 5, 525-527.

 

2002

Pellikka, M., Tanentzapf, G., Pinto, M., McGlade, C.J., Ready D.F. and Tepass, U. (2002) Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis. Nature 416, 143-149.

Beronja, S. and Tepass, U. (2002) Cellular morphogenesis: slow-as-molasses accelerates polarized membrane growth. Dev. Cell 2, 382-384.

Dumstrei, K., Wang, F., Shy, D., Tepass, U. and Hartenstein, V. (2002). Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis. Development 129, 3983-3994. 

Tepass, U. (2002). Adherens junctions: new insight into assembly, modulation and function. BioEssays 24, 690-695.

Tepass, U., Godt, D., and Winklbauer, R. (2002). Cell sorting in animal development: Signalling and adhesive mechanisms in the formation of tissue boundaries. Curr. Opin. Gen. Dev. 12, 572-582.

 

2001-2000

Tepass, U., Tanentzapf, G., Ward, R. and Fehon, R. (2001). Epithelial cell polarity and cell junctions in Drosophila. Ann. Rev. Gen.35, 747-784.

 

Peifer, M. and Tepass, U. (2000). Which way is up? Nature 403, 611-612.

Wilk, R., Reed, B.H., Tepass, U., and Lipshitz, H.D. (2000) The hindsight gene is required for epithelial maintenance and differentiation of the tracheal system in Drosophila. Dev. Biol. 219, 183-196.

Tanentzapf, G, Smith C., McGlade J., and Tepass, U. (2000). Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis. J. Cell. Biol. 151, 891-904.

Tepass U., Truong K., Godt D., Ikura M., and Peifer, M. (2000). Cadherins in embryonic and neuronal morphogenesis. Nat. Rev. Cell Mol. Biol. 1, 91-100.

 

1999-1997

Niewiadomska, P, Godt, D., and Tepass, U. (1999) DE-cadherin is required for intercellular motility during Drosophila oogenesis. J. Cell Biol. 144, 533-547.

Tepass, U. (1999). Genetic analysis of cadherin function in animal morphogenesis. Curr. Opin. Cell Biol. 11, 540-548.

Godt, D. and Tepass, U. (1998). Drosophila oocyte localization is mediated by differential cadherin based adhesion. Nature 395, 387-391.

Lekven, A.C., Tepass, U. Keshmeshian, M., and Hartenstein, V. (1998) faint sausage encodes an Ig-like adhesion molecule required for cell movement and axonal pathfinding in the Drosophila nervous system. Development 125, 2747-2758.

Tepass, U. (1997). Epithelial differentiation in Drosophila. BioEssays 19, 673-682.

 

1996-1994

Hartenstein, V., Tepass, U., and Gruszynski de Feo, E. (1996). Proneural and neurogenic genes control specification and morphogenesis of stomatogastric nerve cell precursors in Drosophila. Dev. Biol. 173, 213-227.

Tepass, U. (1996). Crumbs, a component of the apical membrane controls zonula adherens assembly in Drosophila. Dev. Biol. 177, 217-225.

Tepass, U., Gruszynski de Feo, E, Haag, T., Omatyar, L., Török, T and Hartenstein, V. (1996). shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia. Genes and Dev. 10, 672-685.

Tepass, U. and Hartenstein, V. (1995). Neurogenic and proneural genes control cell type specification in the Drosophila endoderm. Development, 121, 393-405.

Tepass, U., Fessler, L., Aziz, A. and Hartenstein, V. (1994). Embryonic origin of hemocytes and their relation to cell death in Drosophila. Development 120, 1829-1837.

Hartenstein, V., Tepass, U., and Gruszynski de Feo, E. (1994). Structure and embryonic origin of the larval stomatogastric nervous system in Drosophila. J. Comp. Neuro. 350, 367-381. 

Tepass, U. and Hartenstein, V. (1994). The development of cellular junctions in the Drosophila embryo. Dev. Biol. 161, 563-596.

Tepass, U. and Hartenstein, V. (1994). Epithelium formation of the Drosophila midgut depends on interactions between endoderm and mesoderm. Development 120, 579-590.

 

1993-1987

Tepass, U. and Knust, E. (1993). crumbs and stardust act in a genetic pathway that controls the organization of epithelia in Drosophila melanogaster. Dev. Biol. 158,311-326.

Younossi-Hartenstein, A., Tepass, U. and Hartenstein, V. (1993). The embryonic origin of the primordia of the adult Drosophila head. Roux's Arch. Dev. Biol. 203, 60-73.

Knust, E., Tepass, U. and Wodarz, A. (1993). crumbs and stardust, two genes of Drosophila required for the maintenance of epithelial cell polarity. Development, supplement, 261-268.

Hartenstein, A.Y., Rugendorff, A.E., Tepass, U. and Hartenstein, V. (1992). The function of the neurogenic genes during epithelial development in the Drosophila embryoDevelopment 116, 1203-1220.

Tepass, U., Theres, C. and Knust, E.(1990). crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61, 787-799. 

Tepass, U. and Knust, E. (1990). Phenotypic and developmental analysis of mutations at the crumbs locus, a gene required for the development of epithelia in Drosophila melanogaster. Roux's Arch. Dev. Biol. 199, 189-206.

Knust, E., Bremer, K.A., Vässin, H., Ziemer, A., Tepass, U. and Campos-Ortega, J.A. (1987). The Enhancer of split locus and Neurogenesis in Drosophila melanogaster. Dev. Biol. 122, 262-273.

Knust, E., Dietrich, U., Tepass, U., Bremer, K.A., Weigel, D., Vässin, H. and Campos-Ortega, J.A.(1987). EGF homologous sequences encoded in the genome of Drosophila melanogaster, and their relation to neurogenic genes. EMBO. J 3, 761-766.

bioRxiv

 

2021

Sheppard, L., & Tepass, U. (2021). The function of α-Catenin mechanosensing in tissue morphogenesis. bioRxiv.

2019

Laffafian, A., & Tepass, U. (2019). Identification of genes required for apical protein trafficking in Drosophila photoreceptor cells. bioRxiv, 653469.

Silver, J. T., Wirtz-Peitz, F., Simões, S., Pellikka, M., Yan, D., Binari, R., ... & Tepass, U. (2019). The RhoGEF Cysts couples apical polarity proteins to Rho and myosin activity at adherens junctions. bioRxiv, 617134.

Sarpal, R., Yan, V., Kazakova, L., Sheppard, L., & Tepass, U. (2019). Role of α-Catenin and its mechanosensing properties in the regulation of Hippo/YAP-dependent tissue growth. bioRxiv, 567750.